Curated Model: Repressilator, A Synthetic Oscillatory Network
Publication
Elowitz, M., & Leibler, S. (2000). A synthetic oscillatory network of transcriptional regulators. Nature, 403(6767), 335-338.
PMID:10659856
DOI: 10.1038/35002125
BioModels: BIOMD0000000012
Description
This Model describes the oscillatory change in the concentration of tree repressor proteins. LacI is repressor for the transcription of tetR which in turns is repressor for the transcription of cI, finally cI is repressor for the transcription of LacI closing the cycling. The curated VCell Model reproduces the deterministic simulation obtained in BioModels Database, which in turns does not match with the results obtained in the original publication during the first 400 minutes, due to no specification for the initial conditions were given.
Images
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| Vcell: reaction diagram | SBGN visualization |
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| Vcell: Deterministic Simulation | Publication Figure 1C. Oscillation of 3 repressor proteins |
Downloads
| VCell curated model | CM_PM10659856.vcml | Designed with VCell |
| SBML | BIOMD0000000012.xml | Exported from BioModels database |
| GraphML | CM_PM10659856.graphml | Exported from VANTED (SBGN-ED) |
| SBGN-ML | CM_PM10659856.sbgn | Exported from VANTED (SBGN-ED) |
ModelBricks
Contributors
Maria Heredia, Michael Blinov