Curated Models and Related ModelBricks

Publication	ModelBricks
Dynamics of regulatory and signaling pathways in the cell (Curated VCell model, PMID: 12648679)	Protein synthesis and degradation Protein phosphorylation: hyperbolic Protein phosphorylation: sigmoidal Perfectly adapted signal response Activator-inhibitor oscillator Mutual activation Mutual inhibition Negative feedback: homeostasis Negative feedback: oscillator Substrate depletion oscillator
Phosphorylation of PLB by AKAP7 and PKA (Curated VCell model, PMID: 26027516)	Gs Activation cAMP production and degradation PKA activation AKAP7 binds PLB
PDGF regulated activation of Src (Curated VCell model, PMID: 24034255)	PDGF regulated activation of Src
Rho GTPase regulation by RhoGDI & GAP interactions (Curated VCell model, PMID: 25628036)	GEF activation GDI activity Rho GTPase cycle GDI binding
Repressilator: A Synthetic Oscillatory Network (Curated VCell model, PMID: 10659856)	cI represses LacI LacI represses TetR TetR represses cI
Cut out Switch: Rab5 to Rab7 convertion (Curated VCell model, PMID: 18628746)	Rab5 activation Rab7 activation
Minimal model for mitotic oscillator (Curated VCell model, PMID: 1833774)	Mitotic oscillator
Methionine and Threonine Pathways: The Branch - Point (Curated VCell model, PMID: 14622248)	Methionine and Threonine Pathways
HIV latency: Protein interactions & innate immune response (Curated VCell model, PMID: 24997239)	HIV latency
Circaidan clock control by short and long FRQ protein (Curated VCell model, PMID: 18277380)	Transcription of frq Translation of FRQ
Coupled Ca2+ oscillators (Curated VCell model, PMID: 12779457)	Cell Ca2+ oscillation
Positive feedback in mitosis (Curated VCell model, PMID: 27768873)	Positive feedback in mitosis
Auxin regulation of root gravitropism (Curated VCell model, PMID: 22393022)	Gravitropism reduced model Auxin/TIR1 binding