Protein Phosphorylation: Sigmoidal

Publication

Tyson, J. J., Chen, K. C., & Novak, B. (2003).
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Current opinion in cell biology, 15(2), 221-231.

PMID: 12648679   DOI: 10.1016/S0955-0674(03)00017-6

Description

This ModelBrick from the article, “Sniffers, buzzers, toggles and blinkers…” describes protein phosphorylation and dephosphorylation reactions governed by Michelis-Menten kinetics, yielding a sigmoidal signal-response curve.

Reaction Diagram

Images

SBGN visualization	Publication: Simulation

Downloads

VCell ModelBrick	download model (.vcml)	Designed with VCell
SBML	CM_PM12648679_MB2B.xml	Exported from VCell
GraphML	CM_PM12648679_MB2.graphml	Designed with yED
SBGN-ML	CM_PM25628036_MB2.sbgn	Converted with ySBGN

Contributors

Michael Blinov