Perfectly Adapted Signal-Response

Publication

Tyson, J. J., Chen, K. C., & Novak, B. (2003).
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Current opinion in cell biology, 15(2), 221-231.

PMID: 12648679   DOI: 10.1016/S0955-0674(03)00017-6

Description

This ModelBrick from the article, “Sniffers, buzzers, toggles and blinkers…” describes a simple linear response element supplemented with a second signaling pathway (through species X), creating a response mechanism that exhibits perfect adaptation to the signal. Although the signaling pathway exhibits a transient response to changes in signal strength, its steady-state response is independent of the signal strength (S).

Reaction Diagram

Images

SBGN visualization	VCell: Simulation

Downloads

VCell ModelBrick	download model (.vcml)	Designed with VCell
SBML	CM_PM12648679_MB3.xml	Exported from VCell
GraphML	CM_PM12648679_MB3.graphml	Designed with yED
SBGN-ML	CM_PM25628036_MB3.sbgn	Converted with ySBGN

Contributors

Michael Blinov