Negative Feedback: Oscillator

Publication

Tyson, J. J., Chen, K. C., & Novak, B. (2003).
Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell.
Current opinion in cell biology, 15(2), 221-231.

PMID: 12648679   DOI: 10.1016/S0955-0674(03)00017-6

Description

This ModelBrick from the article, “Sniffers, buzzers, toggles and blinkers…” describes negative feedback (X activates Y through phosphorylation, phospho-Y in turn activates R through phosphorylation, with phospho-R degrading X) creating an oscillatory response.

Reaction Diagram

Images

Downloads

VCell ModelBrick	download model (.vcml)	Designed with VCell
SBML

Contributors

Michael Blinov, John Albanese