Curated Model: Ca2+ coupled Cells Oscillators
Publication
Bindschadler, M., & Sneyd, J. (2001). A bifurcation analysis of two coupled calcium oscillators. Chaos: An Interdisciplinary Journal Of Nonlinear Science, 11(1), 237. doi: 10.1063/1.1342161
PMID:12779457
DOI: 10.1063/1.1342161
BioModels: BIOMD0000000058
Description
This Model describes how two coupled cells affect the oscillatory behavior of Ca2+ in each other. The model asumes that Ca2+ enters the cell either by mediation of IP3 receptor or as leaking, and Ca2+ solely leaves the cell by action of ATPase pumps. The simulation resembles the “same amplitude antiphase calcium oscillations of coupled cells” presented in figure 5b in the publication, using the specifications for the IP3R’s concentrations specified in BioModels Database due to no specifications for this species where given in the publication. Also, BioModels suggest that the time t=0 in the publication figure may have been fixed after the system settle, and therefore t=0 of the simulation in BioModels neither in Vcell correspond to the t=0 in the publication.
Images
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| Vcell: reaction diagram | SBGN visualization |
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| Vcell Simulation | Publication Figure 5b. "Same amplitude antiphase calcium oscillations of coupled cells" |
Downloads
| VCell curated model | CM_PM12779457.vcml | Designed with VCell |
| XML | BIOMD0000000058.xml | Exported from BioModels database |
| GraphML | CM_PM12779457.graphml | Exported from VANTED (SBGN-ED) |
| SBGN-ML | CM_PM12779457.sbgn | Exported from VANTED (SBGN-ED) |
ModelBricks
Contributors
Maria Heredia, Michael Blinov