Curated Model: Methionine and Threonine Pathways: The Branch - Point
Publication
Curien, G., Ravanel, S., & Dumas, R. (2003). A kinetic model of the branch-point between the methionine and threonine biosynthesis pathways in Arabidopsis thaliana. European Journal Of Biochemistry, 270(23).
PMID:14622248
DOI: 10.1046/j.1432-1033.2003.03851.x
BioModels: BIOMD0000000068
Description
This Model proposed the Branching of Methionine and Threonine Biosynthesis Pathways in Arabidospsis thaliana, where Cystathionine gamma-synthase (CGS) and Threonine Synthase (TS) compete kinetically for phosphohomoserine. S-adenosylmethionine is the substrat for CGS which is responsible for the synthesis of cystathionine - precursor of methionine- and TS produces threonine.
Images
 |
 |
| Vcell: reaction diagram | SBGN visualization |
 |
 |
| Vcell: Simulation Experimental parameters were set at the moment of simulation (250uM Cistheine and 0.3uM/s of Phosphohoserine flux) |
Publication fig. 2B |
 |
 |
| Ligand concentration dependent plot based on Vcell simulation Simulation run for 10000s in VCell, and the last output flux for Cisthationine and Threonine were used to plot against adenosylmethionine concentration (range 0-100uM). Plot was made using Excel. |
Publication fig. 3C |
Downloads
| VCell curated model | CM_PM14622248.vcml | Designed with VCell |
| XML | BIOMD0000000068.xml | Exported from BioModels database |
| GraphML | CM_PM14622248.graphml | Designed with VANTED (SBGN-ED) |
| SBGN-ML | CM_PM14622248.sbgn | Exported from VANTED (SBGN-ED) |
| XLS | Simulation_results.xls | Ploted in Excel |
Contributors
Maria Heredia, Ann Cowan, Michael Blinov