Curated Model: Circaidan clock control by short and long FRQ protein
Publication
Akman, O. E., Locke, J. C., Tang, S., Carré, I., Millar, A. J., & Rand, D. A. (2008).
Isoform switching facilitates period control in the Neurospora crassa circadian clock.
Molecular Systems Biology, 4(1).
PMID: 18277380
DOI: 10.1038/msb.2008.5
BioModel: BIOMD0000000295
Description
This model of the Neurospora circadian clock illustrates how the parallel, temperature-dependent FRQ feedback loops can give rise to temperature compensation and period control through isoform switching. This model is an extension of an existing model by Leloup et al. (PMID: 10643740). The model involves only the frq gene and demonstrates that the isoform switching mechanism is not specific to a particular set of equations.
Images
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| VCell: Reaction diagram |
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| VCell: Simulation frq mRNA |
VCell: Simulation FRQ |
Publication: Simulation Figure 5 (Supplementary information) |
Downloads
| VCell curated model | CM_PM18277380.vcml | Designed with VCell |
| SBML | BIOMD0000000295.xml | Exported from BioModels database |
ModelBricks
Contributors
John Albanese, Michael Blinov