Curated Model: Minimal model for mitotic oscillator involving cyclin and cdc2 kinase
Publication
Goldbeter, A. (1991).
A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.
Proceedings of the National Academy of Sciences, 88(20), 9107-9111.
PMID: 1833774
DOI: 10.1073/pnas.88.20.9107
BioModel: BIOMD0000000003
Description
This model is based on the cascade of post-translational modification that modulates the activity of cdc2 kinase during the cell cycle. The model pertains to the situation encountered in early amphibian embryos, where the accumulation of cyclin suffices to trigger the onset of mitosis.
Images
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| SBGN visualization | VCell: Reaction diagram |
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| VCell: Simulation | Publication: Simulation Figure 3 |
Downloads
| VCell curated model | CM_PM1833774.vcml | Designed with VCell |
| SBML | BIOMD0000000003.xml | Exported from BioModels database |
| GraphML | CM_PM1833774.graphml | Designed with VANTED (SBGN-ED) |
| SBGN-ML | CM_PM1833774.sbgn | Exported from VANTED (SBGN-ED) |
Contributors
John Albanese, Michael Blinov