Curated Model: Cut-out Switch, Rab5 to Rab7 convertion
Publication
Del Conte-Zerial, P., Brusch, L., Rink, J., Collinet, C., Kalaidzidis, Y., Zerial, M., & Deutsch, A. (2008). Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Molecular Systems Biology, 4.
PMID:18628746
DOI: 10.1038/msb.2008.45
BioModels: BIOMD0000000174
Description
This model describes the convertion of Rab5 to Rab7 in the context of conversion of early endosomes into late endosomes. The VCML executable model correspond to Model #2 named “Cut-out Switch” in Del Conte, P. publication which includes cooperativity of auto-activation loops (marked in red in the SBGN visualization).
Images
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| Vcell: reaction diagram | SBGN visualization |
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| Vcell Simulation | Publication Figure 4D. Numeric Representation of Model 2 |
Downloads
| VCell curated model | CM_PM18628746.vcml | Designed with VCell |
| SBML | BIOMD0000000174.xml | Exported from BioModels database |
| GraphML | CM_PM18628746.graphml | Exported from VANTED (SBGN-ED) |
| SBGN-ML | CM_PM18628746.sbgn | Exported from VANTED (SBGN-ED) |
ModelBricks
Contributors
Maria Heredia, Michael Blinov