ModelBrick1: Cut-out Switch Rab5 activation
Publication
Del Conte-Zerial, P., Brusch, L., Rink, J., Collinet, C., Kalaidzidis, Y., Zerial, M., & Deutsch, A. (2008). Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Molecular Systems Biology, 4.
PMID:18628746
DOI: 10.1038/msb.2008.45
BioModels: BIOMD0000000174
Description
This ModelBrick from the publication, “Membrane identity and GTPase cascades regulated by toggle and cut-out switches” describes Rab5 undergoing cycles of GTP binding and hydrolysis. The authors propose that Rab conversion is operated by a cut-out switch controlled by Rab7.
Reaction Diagram
Images
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| Vcell: Simulation | SBGN visualization |
Downloads
| VCell ModelBrick | download model (.vcml) | Designed with VCell |
| SBML | Exported from VCell | |
| GraphML | CM_PM18628746_MB1.graphml | Created with VANTED (SBGN-ED) |
| SBGN-ML | CM_PM18628746_MB1.sbgn | Exported from VANTED (SBGN-ED) |
Contributors
Maria Heredia, Michael Blinov