ModelBrick 2: Cut-out Switch Rab7 activation
Publication
Del Conte-Zerial, P., Brusch, L., Rink, J., Collinet, C., Kalaidzidis, Y., Zerial, M., & Deutsch, A. (2008). Membrane identity and GTPase cascades regulated by toggle and cut-out switches. Molecular Systems Biology, 4.
PMID:18628746
DOI: 10.1038/msb.2008.45
BioModels: BIOMD0000000174
Description
This ModelBrick from the publication “Membrane identity and GTPase cascades regulated by toggle and cut-out switches” describes Rab activation and hydrolysis. According to this model, Rab5 activates Rab7 until Rab7 reaches a threshold upon which it inactivates Rab5 through a negative feedback loop.
Reaction Diagram
Images
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| Vcell: Simulation | SBGN visualization |
Downloads
| VCell curated model | download model (.vcml) | Designed with VCell |
| SBML | Exported from VCell | |
| GraphML | CM_PM18628746_MB2.graphml | Exported from VANTED (SBGN-ED) |
| SBGN-ML | CM_PM18628746_MB2.sbgn | Exported from VANTED (SBGN-ED) |
Contributors
Maria Heredia, Michael Blinov