Curated Model: Rho GTPase regulation by RhoGDI/GAP interactions
Publication
Ota, T., Maeda, M., Okamoto, M., & Tatsuka, M. (2015).
Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.
BMC systems biology, 9 (1), 3.
PMID: 25628036
DOI: 10.1186/s12918-015-0143-5
Description
This model describes how GEFs and GAPs interact with GDIs in Rho GTPase signaling. GDIs have a negative role in Rho GTPase signaling, as they inhibit GEFs, thereby suppressing overall Rho activity. GDIs also have a positive role, in which they inhibit GAPS under specific conditions, allowing sustained Rho activation.
The curated model
VCell reaction diagram
The model with varying GDI activity
| SBGN visualizations (from publication) |
Simulations (from publication) |
Simulations (from VCell) |
Descriptions |
 |
 |
 |
In this canonical application, GDIs inhibit GEF and GAP activities by sequestering GTPase. Kinetic law was adjusted to eliminate effect of GDI on both GEF and GAP. Figure 1A |
 |
 |
 |
In this GDI-integrated application, GDIs inhibit GEF and GAP activities by sequestering GTPase and by interacting with GEFs and GAPs. Figure 1B |
 |
 |
 |
In this GDI-integrated application, GDI/GEF interaction was removed. Kinetic law was adjusted to eliminate effect of GDI on GEF. Figure 1C |
 |
 |
 |
In this GDI-integrated application, GDI/GAP interaction was removed. Kinetic law was adjusted to eliminate effect of GDI on GAP. Figure 1D |
Downloads
| VCell curated model | CM_PM25628036.vcml | designed with VCell |
| SBML original | CM_PM25628036.xml | Publication |
| GraphML | CM_PM25628036.graphml | exported from VANTED (SBGN-ED) |
| SBGN-ML | CM_PM25628036.sbgn | exported from CellDesigner |
ModelBricks
Contributors
John Albanese, Ann Cowan, Michael Blinov