ModelBrick1: Activation of GEF

Publication

Ota, T., Maeda, M., Okamoto, M., & Tatsuka, M. (2015).
Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.
BMC systems biology, 9 (1), 3.

PMID: 25628036  DOI: 10.1186/s12918-015-0143-5

Description

This ModelBrick from the article, “Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs” describes the activation of GEF and the degradation of the activator. GDIs inhibit GEF and GAP activities by sequestering GTPase (kinetic law was adjusted to eliminate effect of GDI on both GEF and GAP).

Reaction Diagram

Images

SBGN visualization (modified from publication)

Downloads

VCell ModelBrick	download model (.vcml)	Designed with VCell
SBML original	CM_PM25628036_MB1.xml	Modified from publication
GraphML	CM_PM25628036_MB1.graphml	Exported from VANTED (SBGN-ED)
SBGN-ML	CM_PM25628036_MB1.sbgn	Exported from CellDesigner

Contributors

John Albanese, Ann Cowan, Michael Blinov