ModelBrick2: GDI activity in the Rho GTPase cycle

Publication

Ota, T., Maeda, M., Okamoto, M., & Tatsuka, M. (2015).
Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs.
BMC systems biology, 9 (1), 3.

PMID: 25628036  DOI: 10.1186/s12918-015-0143-5

Description

This ModelBrick from the article, “Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs” shows GEF and GAP function integrated in Rho GTPase signaling through GDI interactions. GDIs suppress overall Rho activity by inhibiting GEFs, while GDIs can also sustain Rho activation by inhibiting GAPs under certain conditions. The interconversion between transient and sustained Rho activation occurs mainly through changes in the affinities of GDIs to GAPs and the concentrations of GAPs.

Reaction Diagram

Images

SBGN visualization (modified from publication)

Downloads

VCell ModelBrick	download model (.vcml)	Designed with VCell
SBML original	CM_PM25628036_MB2.xml	Modified from publication
GraphML	CM_PM25628036_MB2.graphml	Exported from VANTED (SBGN-ED)
SBGN-ML	CM_PM25628036_MB2.sbgn	Exported from CellDesigner

Contributors

John Albanese, Ann Cowan, Michael Blinov