Curated VCell Model: Phosphorylation of PLB by AKAP7 and PKA
Publication
Rigatti, M., Le, A.V., Gerber, C., Moraru, I.I. and Dodge-Kafka, K.L., 2015. Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increase phospholamban phosphorylation. Cellular signaling, 27(9), pp.1807-1815.
PMID:26027516
DOI: 10.1016/j.cellsig.2015.05.016
Description
This model describes the binding and phosphorylation of PLB by AKAP7 upon production of cAMP and activation of PKA. A complete description can be found in the paper linked at the publication section. This completed and curated model has been broken up into four ModelBricks listed below.
The curated model
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| VCell: reaction diagram | SBGN-PD visualization |
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| VCell simulation in Curated Model. Run time was set at 10000s to allows the species to reach steady state before stimulation, initial concentration of AKAP is set at 0.38uM. |
Publication figure 5A |
There is a difference between the simulations in the curated model compare to the figure 5A in the publication mainly because the publication does not specify all the parameters for this figure and the author of the original model had tried different parameters which are available in the published Biomodels folder in VCell.
Downloads
| VCell curated model | CM_PM26027516.vcml | Designed with VCell |
| GraphML | CM_PM26027516.graphml | Designed with VANTED (SBGN-ED) |
| SBGN-ML | CM_PM26027516.sbgn | Exported from VANTED (SBGN-ED) |
ModelBricks
Contributors
Maria Heredia, Michael Blinov