ModelBrick 3: PKA activation
Publication
Rigatti, M., Le, A.V., Gerber, C., Moraru, I.I. and Dodge-Kafka, K.L., 2015. Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Cellular signalling, 27(9), pp.1807-1815.
PMID:26027516
DOI: 10.1016/j.cellsig.2015.05.016
Description
This Brick describes the activation of PKA. PKA is a tetramer conformed by two catalytic subunits and two regulatory subunits. The model proposes the activation of the catalytic subunits and allows the regulatory subunits to bind cAMP forming PKA2reg_cAMP(two regulatory subunits binding cAMP) to be later removed from the complex by PDE.
Images
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| Vcell: reaction diagram | VCell: simulation | SBGN visualization |
Downloads
| VCell curated model | CM_PM26027516_MB3.vcml | Designed with VCell |
| SBML | Exported from VCell | |
| GraphML | CM_PM26027516_MB3.graphml | Designed with VANTED (SBGN-ED) |
| SBGN-ML | CM_PM26027516_MB3.sbgn | Exported from VANTED (SBGN-ED) |
Contributors
Maria Heredia, Michael Blinov