ModelBrick 4: AKAP7 binds PLB
Publication
Rigatti, M., Le, A.V., Gerber, C., Moraru, I.I. and Dodge-Kafka, K.L., 2015. Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation. Cellular signalling, 27(9), pp.1807-1815.
PMID:26027516
DOI: 10.1016/j.cellsig.2015.05.016
Description
This brick describes two ways of forming the complex AKAP_pPLB. Where: a) PLB (phospholamban) phosphorylation can be induced by active PKA after binding AKAP or b) previously phosphorylated PLB binds AKAP.
Images
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| Vcell: reaction diagram | Vcell: simulation | SBGN Visualization |
Downloads
| VCell curated model | CM_PM26027516_MB4.vcml | Designed with VCell |
| SBML | Exported from VCell | |
| GraphML | CM_PM26027516_MB4.graphml | Designed with VANTED (SBGN-ED) |
| SBGN-ML | CM_PM26027516_MB4.sbgn | Exported from VANTED (SBGN-ED) |
Contributors
Maria Heredia, Michael Blinov